I knew someone who had been addicted to morphine and alcohol for 30 years, who was drinking quarts of beer and wine daily when he didn't have morphine, who had an opportunity for a good job if he could get sober. Starting progesterone at bedtime (and stopping the wine), he said it was the first time he didn't have a hangover in the morning. He used enough progesterone to neuter most people, but said it didn't affect his sex function; he was taking a lot of Cytomel and magnesium, but wasn't drunk again as long as I knew him, and his general health improved.

[Continued] The person I described who recovered so completely took about 1000 mg of progesterone during the first night, and more than 1000 mg daily for a few weeks, but that much could make some people comatose; it's a matter of individual hormone status. I think the SSRI drugs continue to do harm, even when they reduce withdrawal symptoms.