>>7367
The notable difference would be that "something is missing", something which was an annoyance or a mental strain, a lack of hope or something negative, is no longer present, or you are mentally immune to something which would disturb you before.

As you raise through the planes, there are significant "removals" of this kind for every breakthrough. But the first ones are the most notable because they are the first, and it makes more of an impact on a mostly human mind, compared to later progressions where it's major, significant, but not new as a event type.

If you later on feel that you still want to access blood magic, take a look at the alternatives posted on here recently in terms of using a servitor to represent you as the bloodsucker. There are various ways to do this.