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"Trans -4-hydroxy-2-nonenal (4-HNE) (Figure 1) is a major electrophilic product of lipid peroxidation caused by oxidative stress, which is formed by radical-initiated degradation of ω-6-polyunsaturated fatty acids such as linoleic and arachidonic acids, two relatively abundant fatty acids in human cells (1)."
"... 4-HNE may be an important etiological agent for human cancers that have a mutation at codon 249 of the p53 gene."
https://academic.oup.com/carcin/article/23/11/1781/2608297