>>1508
Depression, health issues, worsening skin, bad smell, hair loss, body hair strengthening (even after laser), loss of femininity in general.

If you ran out of blocker and have no money to buy new, there are at home castration methods. Easiest is the alcohol injenctions, 2ml 95% alcohol, in to each testicle, once per 2 weeks, for about six months. Though don't do more than 2ml or more frequently than 2 week, since necrosis is not a joke and you will need scrotal skin and penis for vaginoplasty.

With no estradiol it is harder, but there are pregnancy pills (these have dangerous ethinylestradiol and other crap) and some people use Bisphenol A as a surrogate. Better use Lena's method to cook cheap injections yourself.