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Бика - блокер рецепторов андрогена, в том числе и в частях мозга, контроллирующих выработку гормонов. Мозг не видит тестостерона и начинает херачить сигналы на выработку еще больших количеств тестостерона и эстрадиола.

https://en.wikipedia.org/wiki/Pharmacology_of_bicalutamide
In men, blockade of the AR by bicalutamide in the pituitary gland and hypothalamus prevents the negative feedback of androgens on the hypothalamic–pituitary–gonadal (HPG) axis, resulting in an increase in luteinizing hormone (LH) secretion and levels.[85] Follicle-stimulating hormone (FSH) levels, in contrast, remain essentially unchanged.[86] The increase in LH levels leads to an elevation in androgen and estrogen levels.[87] At a dosage of 150 mg/day, bicalutamide has been found to increase testosterone levels by about 1.5- to 2-fold (59–97% increase) and estradiol levels by about 1.5- to 2.5-fold (65–146% increase).[63][75][82] However, there is variability in these increases, and in one clinical trial, the highest testosterone concentration that occurred with 50 mg/day bicalutamide monotherapy was 2,306 ng/dL, which was five times the normal average level of testosterone in men.[41][88] Levels of DHT are also increased to a lesser extent (by 24–30%), and concentrations of sex hormone-binding globulin (SHBG) and prolactin increase as well (by 8–42% and 40–65%, respectively) secondary to the increase in estradiol levels.[82][89][90] The estradiol concentrations produced in men by bicalutamide monotherapy are said to approximate the low-normal estradiol levels of a premenopausal woman,[75]