treatment-resistant depression, amisulpride is highly recommended to be taken in conjunction with a primary antidepressant (such as an SSRI or SNRI). In this context, it serves as an augmentation agent (an add-on) rather than a standalone cure. [1, 2, 3]
However, if it is being prescribed for dysthymia (chronic, low-grade depression) or schizophrenia, it can be—and frequently is—prescribed as a monotherapy (taken completely on its own).